Highlander - There are a couple of possibilities.
The easiest one first: make sure "Exit on Mouse Move" is off. Sometimes a mouse can send random signals even when it's not moving.
The other possibility is that something really is running in the background, but you don't know it. Actually, there are probably at least 50 things running in the background on a Vista machine. While they don't usually generate Interrupt messages which would kill the Aquarium, it's been known to happen. Music players, network and Internet routines, MagicJack - make absolutly sure that nothing is trying to bring up a window.
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