I did not get the error in Safe Mode...so it's a conflict, but again, I don't know if it's a conflict with a driver for another program or for Vista x64 itself....Not too terrible as I don't go into the Windows Screen Saver selection/settings panel that often nor into the Serene Screen Settings Panel that often....
If you are interested in finding the conflict, there's a (rather tedious) procedure using msconfig to isolate the problem.