With most modern systems, although it is a concern, the cpu isn't my primary concern. My office machine doesn't hit 100 percent even at -1, and my quad core at home doesn't breathe hard on the cpu no matter what. But, like Cliff says your mileage may vary depending on how old your system is cpu wise.
But your video card is running flat out on lower sleep numbers no matter how new it is. That's why with newer cards you can see 500 fps or something, they have the power to produce that many, but flat out is flat out no matter how many fps it's producing by doing it. And that generates heat. The card can get amazingly hot which is very bad for the card, not to mention the rest of your components by association because that heat has to go somewhere until your system can expell it.
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