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To address the start-up document problem, try rebuilding your desktop database (hold down Command-Option keys when restarting). The start-up document has a creator type that matches the creator type of the MA application (different creator types for MA 1.1, MA 2, and MA Time; different names for the start-up documents for each of these as well). The "original program could not be found" message indicates that the Finder can't find an application in the desktop database with a creator type that matches the document's. Launching the application directly does not involve the desktop database, so it works without problem.
As to the hot corners problem, make sure the hot point of the cursor (the very tip of the pointer, for instance) is in a 10x10 pixel square at the corner of the display and leave it there for at least 10 seconds. The delay is to prevent a momentary pause in regular cursor movement (if it happens in a hot corner) from activating the screen saver.
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